Goat Secondary Antibodies
ABclonal Technology SPR Rabbit pAb
This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1.
ABclonal Technology SCYL2 Rabbit pAb
The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene.
ABclonal Technology U2AF1 Rabbit pAb
This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.
Cayman Chemical NacetylLCysteIn ethyl5mg
An esterified form of NAC; has enhanced cell permeability compared to NAC in isolated perfused rat liver; prevents tert-butyl hydroperoxide-induced formation of methemoglobin in isolated human red blood cells at 1 mM; increases glutathione levels in rat liver, kidney, heart, testis, and brain at 50 mg/kg twice per day; reduces acetaminophen-induced increases in plasma AST, ALT, and LDH levels in rats
Cayman Chemical 1 4ChlorobenzhydrylpIperaz 10g
An inactive metabolite of meclizine and chlorcyclizine; has been found as an impurity in commercial preparations of hydroxyzine and cetirizine; has been used in the synthesis of Nav1.7 inhibitors, anticancer agents, and antihistamines
Cayman Chemical TrnscrIptIonFactrp53Comp1ea
An inhibitor of the protein-protein interaction between Rac1 and TIAM1 inhibits the interaction between Rac1 and TIAM1 in a cell-free assay at 200 UM active against chloroquine-resistant and -susceptible strains of P. falciparum (IC50 17.56 and 12.56 respectively) inhibits the proliferation of MDA-MB-231 F3II and MCF-7 cells (IC50s 48 61 and 31 UM respectively) induces cell cycle arrest at the G1 phase in MDA-MB-231 cells at 10 UM inhibits EGF-induced actin polymerization in and the migration and invasion of MDA-MB-231 and F3II cells at 50 UM reduces the number of lung nodules in an F3II murine model of lung metastasis at 25 mg/kg per day
Cayman Chemical HentrIacontn 250mg
An alkane with anti-inflammatory activity; reduces LPS-induced TNF-α, IL-6, and IL-1β production in RAW 264.7 cells; reduces LPS-induced TNF-α, IL-6 and IL-1β production in whole blood and carrageenan-induced paw edema in mice
ABclonal Technology 488 anti-Human CD263/TRAIL-R3
The protein encoded by this gene is a member of the TNF-receptor superfamily This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain but no cytoplasmic death domain This receptor is not capable of inducing apoptosis and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis This gene was found to be a p53-regulated DNA damage-inducible gene The expression of this gene was detected in many normal tissues but not in most cancer cell lines which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL
ABclonal Technology GEMIN6 Rabbit pAb
GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1, MIM 602595), GEMIN3 (DDX20, MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).
Cayman Chemical CefalothInsodIum salt 5g
A β-lactam cephalosporin antibiotic; inhibits the growth of various Gram-positive and Gram-negative bacteria, including several strains of S. pyogenes, S. aureus, C. tetani, N. gonorrhoeae, Salmonella, and Shigella (MICs = 0.1-0.2, 0.312-0.625, 0.078, 1.25, 1.56-6.25, and 3.12-12.5 μg/ml, respectively); binds to E. coli PBPs (IC50s = S. pyogenes, D. pneumoniae, and S. aureus
Cayman Chemical TrIflupromazInhydrochlorId 10g
A phenothiazine with diverse biological activities; binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay); inhibits 5-HT uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM); inhibits T. cruzi infection in mouse peritoneal macrophages at 12.5 μM; active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml); protective against S. typhimurium infection in mice at 30 μg/animal
ABclonal Technology ISG15 Rabbit pAb
The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted.
Cayman Chemical Goat ntIHumn IgG EuW1024 50ug
Goat Anti-Human IgG, secondary antibody, conjugated to Europium 1024, 20μg Concentration: 1 mg/ml Antibody: Goat poyclonal anti-Human IgG Excitation max. λ: 340 nm Emission max. λ: 615 nm Uses: TR-FRET and High throughput screening (HTS) applications Form: Conjugate supplied as a liquid in 50 mn Tris (pH 7.8) + 0.9% NaCl + 0.05% NaN3.
Cayman Chemical PInacIdIlhydrate 250mg
A potassium channel opener, activating the ATP-modulated potassium channels of guinea pig bladder and heart with Ki values of 104 and 251 nM, respectively; completely relaxes coronary artery rings preconstricted with serotonin (IC50 = 1.26 µM)
ABclonal Technology GNA12 Rabbit pAb
Predicted to enable D5 dopamine receptor binding activity, G-protein beta/gamma-subunit complex binding activity, and GTPase activity. Involved in regulation of TOR signaling and regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in focal adhesion.